Thursday, May 8, 2008: Applied Pharmaceutical Toxicology Day 1
7:30 – 8:30 Registration
8:30 – 8:45 Opening Remarks by Conference
Chairs
Plenary Session
8:45 – 9:30
- Perspectives Regarding Early Safety Assessment, Ronald White,
Global Scientific Advisor, Schering-Plough Research Institute
Session 1:
Strategies in Discovery Toxicology - Where and How to Make the Biggest Impact
Moderator: Bruce Car, BMS
9:30 – 10:45
- Challenges in Predicting the Occurrence of Type B Drug-Induced Liver
Injury(DILI) in Early Drug Discovery, Amit Kalgutkar, Pfizer - Mechanistic Differences in Toxicological Response to Phospholipogenics, Paul Ciaccio, AstraZeneca
10:45 – 11:15 Break
11:15 – 12:30
- Understanding the Off-target Pharmacology of Torcetrapib, Joan Keiser, Pfizer
- Integrated CV Risk Assessment Case Studies, Paul Levesque, BMS
12:30 – 1:30 Luncheon Workshop: Agilent Technologies
Session 2:
Case Studies: Lessons Learned from the Successful and the Not-so-Successful
Moderator: Jim Xu, Pfizer
1:30 – 2:15
- Early Prediction of Clinical Adverse Drug Reactions: in vitro Safety Pharmacology, Laszlo Urban, Novartis
2:15 – 3:30
- Evaluating Mechanism-Based Hepatotoxicity of TNFalpha Converting Enzyme Inhibitors, Lois Lehman-McKeeman, BMS
- Endothelins: A Case Study in Identification of Target-Based Teratogenic Liability, Karen Augustine, BMS
3:30 – 4:00 Break
4:00 – 4:45
- The Preclinical EP/QT Puzzle: Core Issues and Evolving Strategies, Gary Gintant, Abbott
4:45 – 5:15 Roundtable Discussion with Day-1 Speakers
5:15 – 7:15 Wine and Cheese Networking Reception
Friday, May 9, 2008: Applied Pharmaceutical Toxicology Day 2
Plenary Session
8:30 – 9:15
- Perspectives Regarding Early Safety Assessment, Tom Skopek, Senior Scientific Director, Safety Assessment, Merck
Session 3:
Enabling Technologies
Moderator: Kevin Leach, Merck
9:15 – 10:30
- Applications of High Content Screening in Discovery Toxicology, Jim Xu, Pfizer
- Strategies to Reduce NCE Attrition Due to Mitochondrial Toxicity-Designing Novel Screening Methods, Yvonne Will, Pfizer
10:30 – 11:00 Break
11:00 – 12:30
- Cell Line Toxicity Reporters, Kevin Leach, Merck
- Applications of Toxicogenomics in Drug Development, Cynthia Afshari, Amgen
- Using Tissue Engineering in Toxicity Research, Steven Tannenbaum, MIT
12:30 – 1:30 Luncheon Workshop: Cellumen
Session 4:
Emerging Models and Technologies
Moderator: Gerald Miwa
1:30 – 2:45
- Zebrafish in Predictive Discovery Toxicology, Calum MacRae, MGH
- Mice and Knockout Mice in Discovery Risk Assessment, Bruce Car, BMS
2:45 – 3:15 Break
3:15 – 4:30
- Predictive Toxicology using Biomarkers, Frank Hsieh, Nextcea
- Role of Transporters in Toxicity, Keith Hoffmeister, Novartis
4:30 – 5:00 Roundtable Discussion with Day-2 Speakers
5:00 End of Conference
